Nathasia Ayunda Pardina, Sinta Murlistyarini


Introduction: Aging is a dynamic biological process, divided into intrinsic and extrinsic. Hands are often overlooked to care for even though they are areas that are often exposed to the sun. Currently, many botanical topical agents for hand aging, one of which is argan oil.
Case: Female patient, 60 years old, the main complaint is wrinkles on the backs of her hands which are increasing with time and the skin of her hands also feels dry and some brownish spots appear. General examination of the patient is within normal limits. Examination of the dermatological status of the two forearms and the back of the hand revealed hyperpigmented macules, firm borders, multiple, irregular edges, varied in shape and size. There are also fine wrinkles. The patient was diagnosed with solar lentigo and hand aging, the patient was treated with topical argan oil once a day at night, evaluated every 2 weeks until 8 weeks and clinical improvement was obtained with an 11 point reduction based on the Clinical Scale for Forearm Photoaging.
Conclusion: Argan oil is quite effective in reducing signs of skin aging by inhibiting melanin biosynthesis, reducing wrinkles and leaving skin moisturized.


argan oil; hand aging

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Kerns ML, Chien AL, Kang S. Skin Aging. In: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, Orringer JS, editors. Fitzpatrickā€™s Dermatology. 9th ed. New York: Mc-Graw Hill Co. 2019. P.1779-88.

Tobin DJ. Introduction to skin aging. Journal of tissue viability. 2017 Feb 1;26(1):37-46.

Fabi SG, Goldman MP. Hand rejuvenation: a review and our experience. Dermatologic surgery. 2012 Jul;38(7pt2):1112-27.

Gubanova EI, Starovatova PA. A prospective, comparative, evaluator-blind clinical study investigating efficacy and safety of two injection techniques with RadiesseĀ® for the correction of skin changes in aging hands. Journal of Cutaneous and Aesthetic Surgery. 2015 Jul;8(3):147.

Guimaraes, COZ., Bagastin, E., Guadanhim LRS., Sternberg, F., Picosse FR.,Nunes, G. Development and Validation of a clinical scale for the evaluation of forearm skin photoaging. Journal of cutaneous medicine and surgery. 2015.1-8

Amano S. Possible Involvement of basement membrane damage in skin photoaging. J Investig Dermatol Symp Proc. 2009;14(1):2-7.

Campa M, Baron E. Anti-aging effects of select botanicals: scientific evidence and current trends. Cosmetics. 2018 Sep;5(3):54.

Thornton MJ. Estrogens and aging skin. Dermatoendocrinol. 2013;5(2):264-270.

Shamban AT. Combination hand rejuvenation procedures. Aesthet Surg J 2009;29:409-13.

Gold MH, Gallagher C. An evaluation of the benefits of a topical treatment in the improvement of photodamaged hands with age spots, freckles, and/or discolorations. J Drugs Dermatol 2013;12:1468-72.

Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International journal of molecular sciences. 2018 Jan;19(1):70

Vaughn AR, Clark AK, Sivamani RK, Shi VY. Natural oils for skin-barrier repair: ancient compounds now backed by modern science. American journal of clinical dermatology. 2018 Feb 1;19(1):103-17.

Villareal MO, Kume S, Bourhim T, Bakhtaoui FZ, Kashiwagi K, Han J, Gadhi C, Isoda H. Activation of MITF by argan oil leads to the inhibition of the tyrosinase and dopachrome tautomerase expressions in B16 murine melanoma cells. Evidence-Based Complementary and Alternative Medicine. 2013 Jan 1;2013.

Boucetta KQ, Charrouf Z, Aguenaou H, Derouiche A, Bensouda Y. The effect of dietary and/or cosmetic argan oil on postmenopausal skin elasticity. Clinical interventions in aging. 2015;10


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