A COMPARISON OF TRETINOIN AND ADAPALENE IN THE TOPICAL TREATMENT OF MILD TO MODERATE ACNE VULGARIS: LITERATURE REVIEW

Raynanda Kevin Alifiano, Sinta Murlistyarini, Sumarno S

Abstract


 

This research aimed to compare the effectiveness, efficacy, and side effects of adapalene and tretinoin in patients with mild to moderate acne vulgaris. This research was conducted using the literature review method with the approach Systematic Literature Review (SLR) which will be summarized in the form of paper. Researchers collected articles using the keywords acne vulgaris, adapalene, and tretinoin adjusted for Medical Subject Heading (MeSH) and Boolean operators from four databases,PubMed,ScienceDirect,ClinicalTrials.govandWileyOnlineJournal.Asmanyas989journalswereobtainedand continuedwithaselectionusingtheinclusionandexclusioncriteriasetbytheresearcher.Afterthat,thereweresevenjournals that met the criteria therefore that they could be assessed by the quality of the journals using the Critical Appraisal Tools JBI and PICO framework. Researchers found that there was a comparison of the effectiveness of adapalene and tretinoin in the treatmentofacnevulgarisasevidencedfromfivejournalsthatdealtwiththereductioninthenumberofacnelesions,asthree journals stated that adapalene had greater efficacy than tretinoin. In addition, in causing side effects it was stated by all the seven journals that adapalene had lower side effects than tretinoin. Therefore, it is concluded that adapalene has greater efficacyandlowersideeffectsthantretinoin.Forward,researchersrecommendadapaleneasatopicalretinoiddrugofchoice in the treatment of mild to moderate acnevulgaris.


Keywords


acne vulgaris; adapalene; tretinoin

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References


Al-Hammadi A, Al-Ismaily A, Al-Ali S, Ramadurai R, Jain R, McKinley-Grant L, Mughal TI. Topical, Biological and Clinical Challenges in the Management of Patients with Acne Vulgaris. Sultan Qaboos Univ Med J. 2016 May;16(2):e152-60.

Lynn DD, Umari T, Dunnick CA, Dellavalle RP. The epidemiology of acne vulgaris in late adolescence. Adolescent health, medicine and therapeutics. 2016 Jan 19;7:13-25.

Walsh TR, Efthimiou J, Dréno B. Systematic review of antibiotic resistance in acne: an increasing topical and oral threat. Lancet Infect Dis. 2016 Mar;16(3):e23-33.

Tan AU, Schlosser BJ, Paller AS. A review of diagnosis and treatment of acne in adult female patients. Int J Womens Dermatol. 2017 Dec 23;4(2):56-71.

Oon HH, Wong SN, Aw DCW, Cheong WK, Goh CL, Tan HH. Acne Management Guidelines by the Dermatological Society of Singapore. J Clin Aesthet Dermatol. 2019 Jul;12(7):34- 50.

Lens M, Medenica L. Systemic retinoids in chemoprevention of non-melanoma skin cancer. Expert Opin Pharmacother. 2008 Jun;9(8):1363-74.

Thielitz A, Gollnick H. Topical retinoids in acne vulgaris: update on efficacy and safety. Am J Clin Dermatol. 2008;9(6):369-81.

Jain S. Topical tretinoin or adapalene in acne vulgaris: an overview. J Dermatolog Treat. 2004 Jul;15(4):200-7.

Tu P, Li GQ, Zhu XJ, Zheng J, Wong WZ. A comparison of adapalene gel 0.1% vs. tretinoin gel 0.025% in the treatment of acne vulgaris in China. J Eur Acad Dermatol Venereol. 2001;15 Suppl 3:31-6.

Tirado-Sánchez A, Espíndola YS, Ponce-Olivera RM, Bonifaz A. Efficacy and safety of adapalene gel 0.1% and 0.3% and tretinoin gel 0.05% for acne vulgaris: results of a single-center, randomized, double-blinded, placebo-controlled clinical trial on Mexican patients (skin type III-IV). J Cosmet Dermatol. 2013 Jun;12(2):103-7

Grosshans E, Marks R, Mascaro JM, Torras H, Meynadier J, Alirezai M, Finlay AY, Soto P, Poncet M, Verschoore M, Clucas A. Evaluation of clinical efficacy and safety of adapalene 0.1% gel versus tretinoin 0.025% gel in the treatment of acne vulgaris, with particular reference to the onset of action and impact on quality of life. Br J Dermatol. 1998 Oct;139 Suppl 52:26- 33.

Shalita A, Weiss JS, Chalker DK, Ellis CN, Greenspan A, Katz HI, Kantor I, Millikan LE, Swinehart T, Swinyer L, Whitmore C, Baker M, Czernielewski J. A comparison of the efficacy and safety of adapalene gel 0.1% and tretinoin gel 0.025% in the treatment of acne vulgaris: a multicenter trial. J Am Acad Dermatol. 1996 Mar;34(3):482-5.

Cunliffe WJ, Caputo R, Dreno B, Förström L, Heenen M, Orfanos CE, Privat Y, Robledo Aguilar A, Meynadier J, Alirezai M, Jablonska S, Shalita A, Weiss JS, Chalker DK, Ellis CN, Greenspan A, Katz HI, Kantor I, Millikan LE, Swinehart JM, Swinyer L, Whitmore C, Czernielewski J, Verschoore M. Clinical efficacy and safety comparison of adapalene gel and tretinoin gel in the treatment of acne vulgaris: Europe and U.S. multicenter trials. J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S126-34.

Caron D, Sorba V, Kerrouche N, Clucas A. Split- face comparison of adapalene 0.1% gel and tretinoin 0.025% gel in acne patients. J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S110- 2.

Clucas A, Verschoore M, Sorba V, et al. Adapalene 0.1% gel is better tolerated than tretinoin 0.025% gel in acne patients. Journal of the American Academy of Dermatology. 1997 Jun;36(6 Pt 2):S116-8.


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